hydrochlorothiazide, spironolactone, chlorthalidone). Can I Take Lexapro & Vitamin Supplements? J Diet Suppl. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. At the end of the study, significant improvements in general memory and immediate memory were seen in the ashwagandha group. PLoS One 2021;16(9):e0257843. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. They should also be kept from direct sunlight and stored in their original bottle or container. Certain ingredients can influence the effectiveness of your antidepressants and how they affect your health. View abstract. View abstract. Read more: How Vegans Can Get All Their Nutrients (Without Taking Supplements). Some benzodiazepine drugs include alprazolam, known as the brand Xanax; clonazepam, known as Klonopin; diazepam, known as Valium; lorazepam, known as Ativan; and triazolam, known as Halcion. Does Ashwagandha Interact With Any Medications? Some of these interactions can be life-threatening. Information from this source is evidence-based and objective, and without commercial influence. Staff, Cotellic With Turmeric And Black Pepper Interaction. View abstract. Next Steps to Take, Understanding Your Childs Life With ADHD. Indian J Physiol Pharmacol. Does Synthroid interact with supplements that may help with arthritis, such as ashwagandha, collagen, or turmeric? Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. In general, Ashwagandha is thought to be safe when used in moderate amounts. All rights reserved. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Ghosal S, Lal J, Srivastava R, and et al. In large amounts, any of these could potentially affect the way your body processes antidepressants. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. . View abstract. We have said that the elements ashwagandha meds of will ashwagandha interact with diabetic meds cause, ashwagandha interact diabetic principle and ontology are the objects of our research. Remenapp A, Coyle K, Orange T, et al. The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. Kulkarni, S. K. and Dhir, A. Withania somnifera: an Indian ginseng. 2019;11(12):e6466. It is also important to note that ashwagandha may interact with certain medications, such as immunosuppressants and sedatives. Although ashwagandha is mainly considered safe, side effects may be possible. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Doctors prescribe immunosuppressants for people with conditions such as rheumatoid arthritis, psoriasis and ulcerative colitis, and to prevent rejection of organ transplants. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. The Journal of Psychiatry study reported that omega-3 fats and vitamin D are the two essential nutrients that are most likely to help reduce depression symptoms. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. 2020. Ashwagandha may interact with various medications. Ashwagandha may lower blood sugar (i.e. This includes people who have had a transplant, are on chemo, or have an autoimmune disease. Headache. Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. However, there is concern that herbs like ashwagandha may have interactions that have . These medications work in the brain by indirectly enhancing the action of a chemical in the brain called gamma-aminobutyric acid (GABA) a neurotransmitter that has a calming effect which helps lower anxiety levels. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. Discard any remaining ashwagandha supplements once they expire or as indicated on the packaging. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Within this specific study, participants were randomized to receive a placebo (sugar pill with no active ingredients), an ashwagandha dose of 250 milligrams (mg) per day or 600 milligrams per day. 1965;9(1):9-15. This means not enough is known about either the safety or effectiveness of taking daily ashwagandha for an extended period of time. 2019;98(37):e17186. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. Although ashwagandha is one of the more well-studied herbals on the market, there have not been extensive drug-interaction studies with it. Study participants were randomized to receive a placebo, 225 milligrams per day of ashwagandha, or 400 milligrams per day of ashwagandha for 30 days. Of the 58 participants in the study, those who took ashwagandha had reduced levels of cortisol (a stress hormone) as well as lower perceived stress scores by the end of the eight-week study. losartan, valsartan, telmisartan), Beta-Blockers (e.g. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Hi, I was recommended to take ashwagandha. 2022 Mar 25;14(3):e23494. Ashwagandha might increase how much thyroid hormone the body produces. Take ashwagandha with these drugs only under your doctor's supervision, recommends the Langone Medical Center at New York University. Ashwaganda is used to treat Herbal Supplementation. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. 4. Cureus. Role of an indigenous drug Geriforte on blood levels of biogenic amines and its significance in the treatment of anxiety neurosis. Always check with your doctor before you use a natural product. Ashwagandha - More Interactions. You should also review supplement labels with a healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. 2021;270:113766. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. For this reason, it's always best to tell a healthcare provider if you are taking any medications and/or supplements before starting a new supplement. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Some of the more compelling potential uses of ashwagandha are outlined below. Cooley K, Szczurko O, Perri D, et al. Taking it with drugs that increase levels of thyroid hormone (e.g. View abstract. Ashwagandha side effects. 1998;60(2):173-178. Acta Pol.Pharm. Read more: 8 Warning Signs of Depression You Shouldn't Ignore. Neurol India 2009;57:166-71. Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Does Ashwagandha Interact With Any Medications? In recent years, some researchers have assessed how ashwagandha may benefit physical performance. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. PLoS.One. Nutrients. As with many other herbal supplements, little research is available on possible interactions. You will need to talk about the benefits and risks of using this natural product. Learn about the uses and potential benefits of Ashwagandha including dosage guidelines, side effects, interactions and safety/efficacy ratings. This product can contain high amounts of iron. Arch Pathol Lab Med 2007;131:1298-303. View abstract. Ashwagandha's cortisol-lowering effects may be responsible. Ashwagandha can interact with diabetes, blood pressure, and immunosuppressant medications. Tumori 8-31-1994;80(4):306-308. However, these results have not been proven in humans. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. 2020;12(2):e7083. The plan to ashwagandha blood pressure medication interaction enter the company was does blood pressure medication make you put on weight quietly implemented the one from Hebei do hypertension medications affect sexuality University has already started the procedure the Yinchuan University s Zhou Qitian also agreed, and the next step is to do the school work Inner Mongolia can probiotics lower . 2013;12(4):312-22. Chitre D, Nadkarni S, Jagtap N, et al. View abstract. J Ethnopharmacol 1991;33:91-5. Brain Behav. View abstract. Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. View abstract. Ashwagandha (Withania somnifera) is a natural herb used for centuries in Ayurveda. Since you don't mention any drugs in your question, we'll list some of the potential interactions below. Supplements That Are Similar to Ashwagandha. We comply with the HONcode standard for trustworthy health information. Those who took 600 milligrams per day of ashwagandha had better results than those in the 250 milligrams per day group, yet both groups saw improvements in stress. View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Monitor your blood sugar closely. However, many studies supporting the use of ashwagandha are small or poorly designed. Prog.Neuropsychopharmacol.Biol.Psychiatry 7-1-2008;32(5):1093-1105. V. The effect of total alkaloids (ashwagandholine) on the central nervous system. This is because ashwagandha is thought to be an adaptogen, a substance that may help the body resist stress. A few commonly prescribed benzodiazepines are: Alprazolam (Xanax) Clonazepam (Klonopin) Diazepam (Valium) Lorazepam (Ativan) Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. 2022;13(2):100510. doi:10.1016/j.jaim.2021.08.003, Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Ashwagandha is an evergreen shrub that grows in Asia and Africa. View abstract. View abstract. According to the Mayo Clinic, all of these SSRIs work by blocking the reuptake of serotonin in the brain, which essentially makes serotonin more available. However, there is concern that herbs like ashwagandha may have interactions that have not yet been identified. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. 2020;40(4):825-829. Be aware that antidepressants and vitamins typically work with each other the vitamins won't replace your medication. The April 2008 issue of "Therapeutic Drug Monitoring" notes that some herbal products interfere with methodology used to measure drug levels in a patient's bloodstream. The combination could decrease the effectiveness of these medications. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, et al. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Therefore, it is recommended to consult with a healthcare professional before adding ashwagandha to a weight loss plan, especially if you have any underlying medical conditions or are taking any medications . Evid Based Complement Alternat Med. Ashwagandha may interact with certain drugs by enhancing or negating their actions. View abstract. Medical Content Reviewed By HelloPharmacist Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. J Altern Complement Med. Myxedema Coma. A study compared ashwagandha to a placebo to determine whether the herb would have a positive effect on insomnia. This herbal medicine term means that this substance is thought to help the body respond to mental and physical stress and to restore normal emotional and physical body function. National Institutes of Health Office of Dietary Supplements. It was concluded that participants from all five studies found improvements in their anxiety. Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. Some herbal supplements with antidepressant properties are safe to consume alongside medications. Take extra care and check with your doctor if you have: Signs of a very bad reaction. 8-16-1995;95(1-2):189-193. Consult your doctor before taking ashwagandha if you use digoxin. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. It is commonly used for stress. lisinopril, captopril, benazepril, quinapril), ARBs (e.g. View abstract. Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills. 2016;5(4):40. doi:10.3390/antiox5040040, Vitale KC, Hueglin S, Broad E. Tart cherry juice in athletes: a literature review and commentary. However, if you were to combine St. John's wort with antidepressants like SSRIs, you could end up with disastrous results. Taking ashwagandha along with sedative medications might cause too much sleepiness. Some vitamins and supplements can interfere with blood-thinning blood pressure drugs, Dr. Glatter says. J Ethnopharmacol. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. . Talk with a healthcare provider about the right ashwagandha dosage for your needs. Pharmacol Biochem.Behav 2003;75(3):547-555. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. It is mandatory to get consent from the doctor before taking it. Indian J Physiol Pharmacol. Panda S, Kar A. View abstract. These are: In addition to these commonly prescribed antidepressants, there are other central nervous system drugs with antidepressant effects, like antipsychotics, as well as herbs and supplements that have natural antidepressant properties. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Of note, the benefits were strongest in those who took at least 600 milligrams per day of ashwagandha for at least eight weeks. Some products may not mix well with other drugs or natural products. Afewerky HK, Ayodeji AE, Tiamiyu BB, et al. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. 2021;51(4):363-365. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. low blood sugar). Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. It also covers possible side effects of the herb, interactions, dosage information, and guidance regarding selecting ashwagandha supplements. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. View abstract. It's worth noting that a drawback of both these studies is that they were performed on small sample sizes. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. Some people may need to avoid taking Ashwagandha, however, including those who: This is one of the more common food-drug reactions. Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. 2017;14(6):599-612. doi:10.1080/19390211.2017.1284970, Tiwari S, Gupta SK, Pathak AK. Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). Evid Based Complement Alternat Med. 8 Warning Signs of Depression You Shouldn't Ignore, Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, How Vegans Can Get All Their Nutrients (Without Taking Supplements), Complementary Therapies in Medicine Journal, 15 Celebrities Who Struggle With Anxiety and Depression, Australian Journal of Herbal Medicine: "B Vitamins Enhance Antidepressant Response in Adults", Open Neurology Journal: "Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial", Journal of Psychiatry: "Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses", Mayo Clinic: "MAOIs and Diet: Is It Necessary to Restrict Tyramine? 2019;11(10):2362. doi:10.3390/nu11102362, Zhu C, Zhang Y, Wang T, et al. Answered by Dr. Brian Staiger, PharmD View abstract. Ashwagandha might lower blood pressure. Take extra care if you are at a high risk for infection. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. One clinical trial evaluated how ashwagandha root extract affects memory and overall cognitive function. View abstract. ", Mayo Clinic: "Selective Serotonin Reuptake Inhibitors (SSRIs)", Cleveland Clinic: "Depression Medicines: Risks / Benefits", Shanghai Archives of Psychiatry: "Use of Antipsychotics in the Treatment of Depressive Disorders", Food and Drug Administration: "Vitamins and Minerals Chart", World Journal of Biological Chemistry: "Complexity of Vitamin E Metabolism", NCBI Bookshelf: "Depression in Adults With a Chronic Physical Health Problem: Treatment and Management", Journal of Medicine and Life: "Nutrition and Depression at the Forefront of Progress", Harvard Health Publishing: "Cytochrome P450 Enzymes and Psychiatric Drugs", Complementary Therapies in Medicine Journal: "Evaluation of the Efficacy of Withania Somnifera (Ashwagandha) Root Extract in Patients With Obsessive-Compulsive Disorder: A Randomized Double-Blind Placebo-Controlled Trial", Serotonin and norepinephrine reuptake inhibitors (SNRIs), Norepinephrine and dopamine reuptake inhibitors (NDRIs), Noncompetitive N-methyl-D-aspartate receptor antagonists. Malhotra, C. L., Mehta, V. L., Das, P. K., and Dhalla, N. S. Studies on Withania-ashwagandha, Kaul. For example, ashwagandha (botanical name, Withania somnifera) is an herbal supplement found in anything from green smoothie mixes to root powder. Cureus. People who are pregnant or breastfeeding should avoid using the herb, as not enough is known about its safety. ashwaganda ashwagandha (Withania somnifera) Entire Monograph Reported Uses Reported Doses Cautions Drug Interactions Adverse Reactions Synonyms Other Info Add to Interaction Check Biogerontology. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. When multiple foods or supplements are processed by your body via the same exact route, they may compete with one another. J Funct Morphol Kinesiol. Fertil Steril 2010;94:989-96. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Nutrients. According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. Ashwagandha May Interact With Certain Drugs. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. The best time to take ashwagandha is at the time that works best for you. . Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Go to the ER right away. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Ashwagandha may be able to help with insomnia. Among the five cases, ashwagandha dosing ranged from 450 to 1,350 milligrams daily. Withania somnifera, also commonly as ashwagandha or winter cherry, is a shrub native to parts of Asia and Africa. All rights reserved. Serotonin syndrome can even result in death. Cureus 2022;14(10):e30433. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Just be sure to choose a supplement from a reputable manufacturer and follow the . View abstract. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. View abstract. Cureus. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. Thank you, {{form.email}}, for signing up. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Do not use this product if you have stomach problems or ulcers. Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). Never start, stop or otherwise change your therapy before speaking with your provider. These severity listings are for informational use only. The liver damage never progressed to liver failure, and most cases were resolved within five months. Int Ayurvedic Med J 2013;1(5):1-7. Cureus 2022;14(10):e30787. Ashwagandha is considered safe when taken daily for up to three months. 2021;6(1):20. doi:10.3390/jfmk6010020, Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. 2019;98(37):e17186. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.